Spondyloarthritides: Theories and beyond.
Begüm Kocatürk1, Zeynep Balık2, Gaye Pişiren1
1Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Frontiers in Pediatrics
|January 9, 2023
Summary
Spondyloarthritides (SpA) are rheumatic diseases impacting quality of life. Accurate diagnosis and emerging treatments like JAK inhibitors are key for managing SpA, with ongoing research into risk factors like HLA-B27.
Area of Science:
- Rheumatology and Immunology
- Inflammatory Arthritis Research
- Clinical Diagnostics
Background:
- Spondyloarthritides (SpA) encompass related rheumatic disorders with early onset, significantly impacting patient quality of life.
- Understanding SpA etiology is incomplete, but HLA-B27 positivity is a strong risk factor, though not universally present.
- Current management involves NSAIDs, TNF inhibitors, DMARDs, and physiotherapy, with novel therapies under investigation.
Purpose of the Study:
- To review current diagnostic criteria for SpA.
- To provide an overview of existing and emerging SpA treatment strategies.
- To explore potential risk factors and theories contributing to SpA pathogenesis, focusing on Ankylosing Spondylitis (AS) and enthesitis-related arthritis (ERA).
Main Methods:
- Literature review of diagnostic criteria updates.
- Analysis of current therapeutic interventions for SpA.
- Synthesis of research on SpA risk factors and pathogenetic theories.
Main Results:
- Diagnostic criteria for SpA are regularly updated to improve accuracy.
- Established treatments include NSAIDs, TNFis, DMARDs, and physiotherapy.
- Emerging treatments include anti-IL17 agents and JAK inhibitors, with ongoing clinical trials.
Conclusions:
- Accurate diagnosis is crucial for effective SpA management.
- A combination of established and novel therapies offers improved treatment prospects.
- Further research into SpA pathogenesis, including non-HLA-B27 factors, is essential for comprehensive understanding and treatment.
Keywords:
ankylosing spondylitisenthesitis-related arthritismedical biologyrheumatologyspondyloarthritidesMore Related Videos
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