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Updated: Aug 14, 2025

Prion Safety Laboratory Swipe Test
Published on: February 14, 2025
Diagnostic approach in a patient with Creutzfeldt-Jakob disease
José Wagner Leonel Tavares-Júnior1, Renata de Oliveira Carvalho2, Raul Raposo Pereira Feitosa3
1Universidade Federal do Ceará, Departamento de Clínica Médica, Fortaleza, CE, Brazil.
Abstract:
Prion diseases are an important cause of rapidly progressive dementias. Among them, the most common is sporadic Creutzfeldt-Jakob disease (CJD). It is a rare and incurable disease, with rapid progression to death.
Objective:
To describe the diagnostic approach of a patient with Creutzfeldt-Jakob disease.
Methods:
The diagnosis is established through the clinical picture associated with characteristic changes in the brain magnetic resonance imaging, the electroencephalogram, and analysis of specific changes in the cerebrospinal fluid.
Results:
The present report describes the case of a 53-year-old patient in the city of Fortaleza-CE. The diagnosis was made based on the clinical condition and through diagnostic tests, including 14-3-3 protein and RT QUIC analysis. Differential diagnosis was performed with other rapidly progressive causes, such as infectious and immune-mediated diseases.
Conclusions:
The diagnosis of probable sporadic CJD was established.
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