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Steady-state, Pre-steady-state, and Single-turnover Kinetic Measurement for DNA Glycosylase Activity
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OGG1 in the Kidney: Beyond Base Excision Repair
Fan Zhao1, Jiefu Zhu2, Lang Shi1
1Department of Nephrology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
Oxidative Medicine and Cellular Longevity
|January 9, 2023
Summary
8-Oxoguanine DNA glycosylase (OGG1) repairs damaged DNA and regulates gene transcription. This review explores OGG1
Area of Science:
- Molecular Biology
- Genetics
- Biochemistry
Background:
- 8-Oxoguanine DNA glycosylase (OGG1) is crucial for repairing 8-oxoguanine (8-oxoG) DNA lesions via the base excision repair pathway.
- OGG1 participates in DNA repair, oxidative stress response, inflammation, fibrosis, and autophagy, with roles in cytoplasm, nucleus, and mitochondria.
Purpose of the Study:
- To review the structure, biological functions, and regulatory mechanisms of OGG1 in kidney disease.
- To discuss the potential of OGG1 as a therapeutic target for kidney diseases.
Main Methods:
- Literature review of OGG1's role in kidney disease progression.
- Analysis of OGG1's involvement in DNA repair, inflammation, autophagy, and epigenetic regulation.
Main Results:
- OGG1 plays a significant role in kidney disease progression through DNA repair, inflammation induction, and autophagy regulation.
- Epigenetic effects of OGG1 in kidney disease are increasingly recognized.
Conclusions:
- OGG1 is implicated in various physiological processes and kidney disease pathogenesis.
- Targeting OGG1 presents a potential therapeutic strategy for kidney diseases.
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