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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

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Chronic kidney disease and NLRP3 inflammasome: Pathogenesis, development and targeted therapeutic strategies

Gengzhen Huang1,2, Yaodan Zhang3, Yingying Zhang1

  • 1Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Biochemistry and Biophysics Reports
|January 9, 2023
PubMed

Insights

Chronic kidney disease (CKD) involves inflammation, often driven by the NLRP3 inflammasome. Targeting this inflammasome offers promising new treatments for kidney disease.

Area of Science:

  • Nephrology
  • Immunology
  • Molecular Biology

Background:

  • Chronic kidney disease (CKD) is a global health issue characterized by inflammation and toxin accumulation.
  • Inflammation in CKD contributes to kidney dysfunction and fibrosis.
  • The NLR family pyrin domain containing 3 (NLRP3) inflammasome is implicated in renal inflammation.

Purpose of the Study:

  • To review current knowledge on the role of the NLRP3 inflammasome in CKD.
  • To explore novel therapeutic strategies targeting the NLRP3 inflammasome for CKD treatment.

Main Methods:

  • Literature review of recent findings on NLRP3 inflammasome activation in CKD.
  • Analysis of studies investigating small molecule inhibitors of the NLRP3 inflammasome.

Main Results:

  • NLRP3 inflammasome activation exacerbates renal inflammation and promotes pyroptotic cell death in CKD.
  • The precise mechanisms of inflammasome activation in CKD require further elucidation.
  • Small molecule inhibitors targeting NLRP3 show potential for CKD treatment.

Conclusions:

  • The NLRP3 inflammasome is a key mediator in the pathogenesis of CKD.
  • Targeting the NLRP3 inflammasome represents a promising therapeutic avenue for managing CKD.
Keywords:
,IL-18, Interleukin-18ASC, apoptosis-associated speck-like proteinAng II, Angiotensin IICKD, Chronic kidney diseaseChronic kidney diseaseDAMPs, damage-associated molecular patternsESRD, End-stage renal diseaseGFR, glomerular filtration rateHK-2, renal tubular epithelial cellsIL-1β, Interleukin-1βInflammasomeKidney functionLRR, leucine-rich repeatNEK7, NIMA-related kinase 7NF-kB, nuclear factor kappa-BNLRP3, NLR family pyrin domain containing 3NOD-like receptorPAMPs, Pathogen-associated molecular patternsROS, reactive oxygen speciesTXNIP, thioredoxin-interacting protein

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