Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.

eLife·2026
Same author

Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.

bioRxiv : the preprint server for biology·2026
Same author

Retrograde control of sympathetic neuron-satellite glia interactions by target-derived NGF signaling.

Cell reports·2025
Same author

Excitatory and inhibitory neurotransmitter alterations with advancing age and injury in the mouse retina.

Neurobiology of aging·2025
Same author

Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.

bioRxiv : the preprint server for biology·2024
Same author

Retinal Connectomics: A Review.

Annual review of vision science·2024
Same journal

Editorial: Updates and discussions about basal ganglia and their circuits.

Frontiers in neuroanatomy·2026
Same journal

TC2-Res: a structured fusion of tract-level and connectome-level brain imaging in small-sample cohorts of athletes.

Frontiers in neuroanatomy·2026
Same journal

Revisiting the clastosome: a stress-induced nuclear proteolytic compartment of mammalian cells.

Frontiers in neuroanatomy·2026
Same journal

Intrinsic elaboration of prefrontal modularity: a dual-control model of axon bundling and synaptic docking.

Frontiers in neuroanatomy·2026
Same journal

Selective enrichment of TCF4 in GABAergic neurons during postnatal primate development.

Frontiers in neuroanatomy·2026
Same journal

ATF3-based peripheral neural tract tracing.

Frontiers in neuroanatomy·2026
See all related articles

Related Experiment Video

Updated: Aug 14, 2025

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
10:24

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

10.2K

Current perspective on retinal remodeling: Implications for therapeutics.

Rebecca L Pfeiffer1, Bryan W Jones1

  • 1Moran Eye Center, Department of Ophthalmology, University of Utah, Salt Lake City, UT, United States.

Frontiers in Neuroanatomy
|January 9, 2023
PubMed
Summary
This summary is machine-generated.

Retinal remodeling complicates vision loss from diseases like retinitis pigmentosa. Understanding this remodeling is key for developing effective vision-restoring therapies.

Keywords:
age-related macular degenerationneurodegenerationretinal remodelingretinitis pigmentosatherapeutics

More Related Videos

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.0K
Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

14.5K

Related Experiment Videos

Last Updated: Aug 14, 2025

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
10:24

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

10.2K
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.0K
Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
07:32

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina

Published on: June 23, 2014

14.5K

Area of Science:

  • Ophthalmology and Neuroscience

Background:

  • Retinitis pigmentosa and age-related macular degeneration cause irreversible vision loss.
  • These diseases involve progressive photoreceptor degeneration and retinal remodeling.

Purpose of the Study:

  • To review the current understanding of retinal remodeling.
  • To discuss its implications for vision-restoring therapeutics.
  • To explore combined therapeutic strategies and the retina as a neurodegeneration model.

Main Methods:

  • Perspective review of current research on retinal remodeling.
  • Analysis of challenges posed by retinal remodeling for therapeutic strategies.
  • Discussion of combined therapeutic approaches and neurodegeneration modeling.

Main Results:

  • Retinal remodeling presents significant challenges for current vision-restoring therapies.
  • A comprehensive understanding of retinal remodeling is crucial for therapeutic development.
  • Combined strategies using diffusible molecules may enhance therapeutic efficacy.

Conclusions:

  • Understanding retinal remodeling is essential for advancing vision restoration.
  • The retina serves as a valuable model for studying neurodegeneration.
  • Future therapeutics may benefit from combined approaches and a deep knowledge of retinal changes.