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Methotrexate neuroenteropathy--a histochemical study
M G el-Badawi1, J A Fatani, M A Qayyum
1Department of Anatomy, College of Medicine, Riyadh, Saudi Arabia.
Anatomischer Anzeiger
|January 1, 1987
Abstract:
10 mg/kg Methotrexate was injected daily for 5 d a week for a total period of 3 weeks and its effect on autonomic nerve profiles of jejunum was studied using histochemical methods. Initially (after 5 doses in a week) partial degeneration of adrenergic and cholinergic nerve supply was observed. Prolonged treatment (15 does in 3 weeks) was responsible for disappearance of about 30% of adrenergic and 50% of cholinergic nerve profiles. Early degenerative changes in the cholinergic nerve cells of the intestinal plexuses was also noted.