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Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

401
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
401

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Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse
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Echocardiography protocol: A tool for infrequently used parameters in mice.

Emily Ann Todd1, Monique Williams2,3, Ali Kamiar2,3

  • 1Department of Medical Education, University of Miami Leonard M. Miller School of Medicine, Miami, FL, United States.

Frontiers in Cardiovascular Medicine
|January 9, 2023
PubMed
Summary

This guide offers standardized echocardiography methods for rodent cardiovascular research. It clarifies interpretation of key cardiac parameters to improve consistency in studies of mouse models.

Keywords:
aortic regurgitationcardiovascular diseaseechocardiographyleft ventricular outflow tractmitral regurgitationmitral stenosispulmonary regurgitationright ventricular outflow tract

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Area of Science:

  • Cardiovascular Research
  • Medical Imaging
  • Animal Models

Background:

  • Echocardiography is vital for assessing cardiac function in rodent models of cardiovascular disease.
  • Current protocols lack standardization for many crucial echocardiography parameters, leading to subjective interpretation and conflicting literature.
  • Infrequently used parameters, such as valve regurgitation and stenosis, are often equivocal, hindering comprehensive analysis.

Purpose of the Study:

  • To provide a practical guide for acquiring and interpreting less common echocardiography parameters in rodent models.
  • To establish a standardized framework for comprehensive analysis of cardiac structure and function.
  • To improve consistency and reduce ambiguity in echocardiography data interpretation within cardiovascular research.

Main Methods:

  • Detailed protocols for acquiring echocardiography data focusing on right ventricle (RV), pulmonary artery (PA), pulmonary valve (PV), left atrium (LA), mitral valve (MV), and aortic valve (AoV).
  • Guidelines for the interpretation of parameters including mitral regurgitation, mitral stenosis, pulmonary regurgitation, and aortic regurgitation.
  • Emphasis on objective measurements and standardized views to minimize subjective interpretation.

Main Results:

  • A framework for comprehensive echocardiographic analysis of rodent cardiovascular models is presented.
  • Standardized methods for evaluating RV, PA, PV, LA, MV, and AoV function and structure are described.
  • The guide aims to resolve ambiguities in interpreting parameters like valve regurgitation and stenosis.

Conclusions:

  • Standardized echocardiography protocols are essential for reliable evaluation of rodent cardiovascular disease models.
  • This guide facilitates more accurate and consistent interpretation of complex echocardiography parameters.
  • Implementing these methods will enhance the reproducibility and clarity of published cardiovascular research in rodents.