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Published on: December 7, 2013
A Descriptive Study of Atherogenic Indices in Patients Admitted to a Tertiary Care Hospital
Saranya Dharmaraj1, Sujatha Rajaragupathy2, Saju Denishya2
1Biochemistry, Employees' State Insurance Corporation (ESIC) Medical College, Hyderabad, IND.
Insights
Atherogenic indices, like non-high-density lipoprotein cholesterol, may indicate coronary artery disease and statin use in hospitalized patients. However, these indices do not reliably predict hospital stay duration.
Area of Science:
- Cardiology
- Clinical Biochemistry
- Public Health
Background:
- Atherogenic indices are valuable, non-invasive tools for assessing dyslipidemias and cardiometabolic risk.
- Evaluating these indices in hospitalized patients can aid in prognosis and management.
Purpose of the Study:
- To assess atherogenic index profiles in hospitalized patients.
- To correlate these indices with comorbidities, statin use, and hospital stay duration.
Main Methods:
- Cross-sectional study of 412 hospitalized adults (>18 years).
- Calculation of atherogenic indices from lipid profiles.
- Statistical analysis using Mann-Whitney U and Spearman's rank correlation tests.
Main Results:
- Non-high-density lipoprotein cholesterol showed significant association with coronary artery disease (p=0.0112) and statin use (p=0.0057).
- No significant differences in other atherogenic indices across comorbidities or statin use.
- Atherogenic indices did not correlate with hospital stay duration (p>0.05).
Conclusions:
- Non-high-density lipoprotein cholesterol may serve as a potential biomarker for coronary artery disease and statin use.
- Other traditional atherogenic indices are not reliable predictors of hospital stay duration in this cohort.
Abstract:
Introduction Atherogenic indices, as common factors implicated in the pathogeneses of atherogenic dyslipidemias and cardiometabolic disorders, provide inexpensive and less invasive aids for assessing the prognosis of hospitalized patients. Hence, we evaluate the atherogenic index profiles of patients admitted to a tertiary care hospital and correlate them with comorbidities, statin use, and duration of hospital stay. Methodology This cross-sectional study included 412 hospitalized patients aged >18 years undergoing lipid profiling, irrespective of their diagnosis. Their atherogenic indices were calculated from their lipid profile parameters and correlated with their comorbidities, statin use, and duration of hospital stay. Statistical analysis was done using the Mann-Whitney U test and Spearman's rank correlation coefficient tests, with a p-value of <0.05 indicating statistical significance. Results The participating cohort showed a mean age of 56.01±13.32 years. Nearly 63.0% of these had diabetes mellitus, 52.0% had hypertension, 34.0% had coronary artery disease, 16.0% had a cardiovascular accident, and 16.5% reported statin use. There was no significant difference in the distribution of any of the atherogenic indices over any of the comorbidities like diabetes mellitus, hypertension, coronary artery disease, or statin use, except for the non-high-density lipoprotein cholesterol distribution, which was significantly associated with coronary artery disease (p-value = 0.0112) and statin use (p-value = 0.0057). Atherogenic indices were not correlated with the duration of hospital stay (p-value > 0.05). Discussion This study suggests that non-high-density lipoprotein cholesterol may serve as an indicator of coronary artery disease and statin use. However, other atherogenic indices may not serve as reliable predictors of the duration of a hospital stay.
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