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Behavioral profiling of SLC38A10 knockout mice using the multivariate concentric square fieldTM test
Frida A Lindberg1, Erika Roman2,3, Robert Fredriksson1
1Department of Pharmaceutical Biosciences, Molecular Neuropharmacology, Uppsala University, Uppsala, Sweden.
Frontiers in Behavioral Neuroscience
|January 9, 2023
Summary
The SLC38A10 gene knockout mouse model showed no drastic behavioral changes in the multivariate concentric square field (MCSF) test. Subtle alterations in exploratory behavior and risk assessment were observed in male and female mice, respectively.
Area of Science:
- Neuroscience
- Genetics
- Behavioral Science
Background:
- SLC38A10, also known as SNAT10, is an evolutionarily ancient member of the SLC38 gene family.
- It is ubiquitously expressed and transports amino acids like glutamine, glutamate, alanine, aspartate, and serine.
- The biological significance of SLC38A10 remains largely uncharacterized.
Purpose of the Study:
- To investigate the behavioral impact of SLC38A10 loss of function in mice.
- To assess the role of SLC38A10 in exploratory behavior and risk assessment using the MCSF test.
Main Methods:
- An SLC38A10 knockout mouse model was utilized.
- Mice were subjected to the multivariate concentric square field (MCSF) test to evaluate behavioral choices.
- Multivariate data were analyzed for individual parameters, grouped functional categories, and principal component analysis.
Main Results:
- Knockout mice exhibited decreased exploratory behavior compared to controls.
- No distinct grouping was observed in the principal component analysis of the knockout mice.
- While no pronounced overall behavioral differences were noted, subtle alterations in exploratory and risk assessment zones were observed in female and male knockout mice, respectively.
Conclusions:
- Loss of SLC38A10 function in mice does not lead to drastic behavioral alterations in the MCSF test.
- The study suggests a nuanced role for SLC38A10 in specific aspects of mouse behavior, particularly in exploratory and risk assessment contexts.
- Further research is warranted to fully elucidate the biological importance of SLC38A10.
