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Updated: Aug 14, 2025

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The function of miR-145 in colorectal cancer progression; an updated review on related signaling pathways

Nazila Mozammel1, Mohammad Amini1, Behzad Baradaran1

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Pathology, Research and Practice
|January 9, 2023
PubMed

Insights

MicroRNAs (miRNA) are key regulators in cancer. This study highlights miR-145

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • Dysregulated miRNAs are implicated in various human cancers.
  • miR-145 is a tumor suppressor miRNA with altered expression in malignancies.

Purpose of the Study:

  • To review recent findings on miR-145 functions in colorectal cancer (CRC).
  • To elucidate miR-145's role in CRC incidence and progression.
  • To understand miR-145's interplay with signaling pathways in CRC.

Main Methods:

  • Literature review of articles indexed in PubMed and Google Scholar until 2021.
  • Analysis of studies focusing on miR-145 expression and function in colorectal cancer.
  • Examination of miR-145's regulatory roles in key cancer-related signaling pathways.

Main Results:

  • miR-145 is downregulated in colorectal cancer (CRC).
  • Downregulation of miR-145 promotes CRC cell growth, invasion, metastasis, and drug resistance.
  • miR-145 targets genes involved in KRAS and P53 signaling pathways, influencing colorectal tumorigenesis.

Conclusions:

  • miR-145 functions as a crucial tumor suppressor in colorectal cancer.
  • Restoring miR-145 levels holds potential for CRC diagnosis and therapy.
  • Understanding miR-145's pathway interactions is vital for targeting CRC progression.
Keywords:
ApoptosisColorectal cancerMetastasisSignaling pathwaysmicroRNA-145

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