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Long-term IgG4 determinations in hymenoptera-sensitive treated patients.

M J Gentlesk1, G M Halpern, H C Mansmann

  • 1Division of Allergy and Clinical Immunology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania.

Annals of Allergy
|October 1, 1987
PubMed
Summary

Long-term venom immunotherapy for Hymenoptera stings shows that venom-specific IgG4 antibody levels plateau then decline after three years. Despite low IgG4, patients remained clinically protected, suggesting different mechanisms for short-term and long-term immunity.

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