Related Experiment Videos
Plasma histamine levels in normal and atopic children
T Fujisawa1, M Komada, K Iguchi
1Department of Pediatrics, Mie National Hospital, Mie Prefecture, Japan.
Annals of Allergy
|October 1, 1987
Summary
Children with atopic disease have higher plasma histamine levels, which correlate with disease severity. These findings highlight histamine
Area of Science:
- Pediatric Allergy and Immunology
- Clinical Chemistry
Background:
- Histamine is a key mediator in allergic reactions.
- Understanding histamine levels in children is crucial for diagnosing and managing atopic conditions.
Purpose of the Study:
- To determine normal plasma histamine levels in children across different age groups.
- To investigate the relationship between plasma histamine levels and atopic disease severity.
- To explore correlations between plasma histamine, basophil count, and immunoglobulin E (IgE) in children.
Main Methods:
- Plasma histamine was quantified in 258 children using high-performance liquid chromatography (HPLC).
- Age-specific normal histamine levels were established.
- Histamine levels were compared between atopic and non-atopic children.
- Correlations with clinical parameters were analyzed.
Main Results:
- Normal plasma histamine levels decreased with age.
- Atopic children exhibited significantly higher plasma histamine levels compared to normal children.
- A positive correlation was observed between the extent of atopic disease and plasma histamine levels.
- Significant correlations between plasma histamine and basophil count/IgE were found in atopic children, but not in normal children.
Conclusions:
- Plasma histamine levels serve as a potential biomarker for atopic disease in children.
- Age-dependent reference ranges for plasma histamine are important.
- The study confirms the involvement of histamine in the pathophysiology of atopic conditions in pediatric populations.