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Protein SUMOylation and phase separation: partners in stress?

Xiaodong Cheng1

  • 1Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Texas Therapeutics Institute, Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Trends in Biochemical Sciences
|January 9, 2023
PubMed
Summary

Protein SUMOylation, a key cellular process, is regulated by liquid-liquid phase separation (LLPS). This finding helps explain how cells manage SUMOylation under stress, maintaining homeostasis.

Keywords:
SUMOylationbiomolecular condensateliquid–liquid phase separationmultivalent interactionstress response

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