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Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Bone microstructure in proton pump inhibitor users.

Ananya Kondapalli1, Sanchita Agarwal1, Carmen Germosen1

  • 1Division of Endocrinology, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA.

Bone
|January 9, 2023
PubMed
Summary
This summary is machine-generated.

Proton pump inhibitor (PPI) use in older adults did not impact bone microstructure or stiffness. This study found no evidence linking PPIs to detrimental skeletal changes in elderly individuals.

Keywords:
FractureMicrofinite element analysisMicrostructureProton pump inhibitorVolumetric bone density

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Area of Science:

  • Gerontology
  • Bone Metabolism
  • Pharmacology

Background:

  • Proton pump inhibitors (PPIs) are widely prescribed for acid-related gastrointestinal disorders.
  • Concerns exist regarding potential adverse effects of long-term PPI use on bone health.
  • Previous studies have yielded conflicting results on the association between PPIs and fracture risk.

Purpose of the Study:

  • To investigate the relationship between proton pump inhibitor (PPI) use and skeletal microstructure and stiffness in older adults.
  • To evaluate potential dose-dependent effects of PPIs on bone parameters.
  • To compare bone health metrics between PPI users and non-users using advanced imaging techniques.

Main Methods:

  • Cross-sectional study of 601 elderly adults (≥65 years), including 130 PPI users and 471 non-users.
  • High-resolution peripheral quantitative computed tomography (HRpQCT) and microfinite element analysis (μFEA) were employed to assess bone microstructure and mechanical properties.
  • Covariate adjustments were made to account for potential confounding factors.

Main Results:

  • PPI users, particularly women, reported more comorbidities, falls, and historical fractures compared to non-users.
  • No significant differences in skeletal microstructure or stiffness (HRpQCT, μFEA) were observed between female PPI users and non-users.
  • Male PPI users showed a slight decrease in tibial cortical volumetric bone density, but stiffness was not affected.

Conclusions:

  • Proton pump inhibitor (PPI) use was not associated with altered skeletal microstructure or stiffness in this cohort of elderly men and women.
  • The findings do not support a direct link between PPI usage and detrimental changes in bone structural integrity.
  • Further research may be warranted to explore other potential non-skeletal adverse effects of PPIs.