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Related Concept Videos

Insomnia01:27

Insomnia

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Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
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Management of Insomnia01:19

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The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Substance Use Disorders Affecting Sleep01:24

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Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
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Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

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Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Predicting insomnia severity using structure-function coupling in female chronic insomnia patients.

Dongyan Wu1, Xinzhi Wang2, Shiqi Lin2

  • 1Department of Neurology, China-Japan Friendship Hospital, Beijing, PR China.

Behavioural Brain Research
|January 9, 2023
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Summary

Brain structure and function coupling can predict insomnia severity in women. Insomnia is linked to altered coupling in higher-order brain regions and increased coupling in lower-order areas.

Keywords:
Female chronic insomniaIndividualized predictionInsomnia severity indexStructure-function coupling

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Sleep Medicine

Background:

  • Functional brain connectivity is influenced by structural pathways.
  • The disruption of structure-function coupling in female insomnia disorder is not well understood.

Purpose of the Study:

  • To investigate if whole-brain structure-function coupling patterns can predict insomnia severity in female patients.
  • To identify brain regions contributing to this predictive relationship.

Main Methods:

  • Resting-state functional MRI and diffusion-weighted imaging were used in 82 female participants with chronic insomnia.
  • Structure-function coupling was calculated using Spearman correlations between structural and functional connectivity.
  • Relevance vector regression with 10-fold cross-validation predicted insomnia severity index (ISI) from coupling patterns.

Main Results:

  • The whole-brain structure-function coupling pattern significantly predicted ISI (r=0.29, P<0.001, MAE=4.59).
  • Higher functional hierarchy regions (e.g., default mode network) showed negative contribution weights.
  • Lower functional hierarchy regions (e.g., occipital, precentral gyrus) showed positive contribution weights.

Conclusions:

  • This is the first study linking structure-function coupling to insomnia severity in females.
  • Insomnia severity correlates with reduced coupling in higher-order brain regions and increased coupling in lower-order regions.