Related Experiment Video
Updated: Aug 14, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Linking chronic diseases, cognitive impairment and depressive symptoms in Chinese older adults: A three-wave
Chaoxin Jiang1, Chong Hu2, Dandan Li2
1Department of Social Welfare and Risk Management, School of Public Affairs, Zhejiang University, Hangzhou, Zhejiang, China.
Insights
Chronic diseases negatively impact older adults
Area of Science:
- Gerontology
- Public Health
- Psychiatry
Background:
- Chronic diseases are established risk factors for psychological health in older adults.
- The mediating mechanisms linking chronic diseases to psychological distress remain underexplored.
- The influence of China's Hukou system on this relationship requires further investigation.
Purpose of the Study:
- To investigate the mediating role of cognitive impairment in the association between chronic diseases and depressive symptoms.
- To examine the moderating effect of the Hukou system on the relationship between chronic diseases and depressive symptoms in Chinese older adults.
Main Methods:
- Utilized data from the China Longitudinal Aging Social Survey (CLASS) 2014, 2016, and 2018.
- Employed fixed-effect panel models to analyze the effects of chronic diseases on depressive symptoms.
- Assessed the mediating role of cognitive impairment and the interaction effect of Hukou status.
Main Results:
- Confirmed a significant association between chronic diseases and depressive symptoms in Chinese older adults.
- Cognitive impairment significantly mediates the relationship between chronic diseases and depressive symptoms.
- No significant urban-rural disparities were found in the effect of chronic diseases on depressive symptoms.
Conclusions:
- Cognitive impairment is a key mediator linking chronic diseases to depression in older Chinese adults.
- The Hukou system does not appear to create urban-rural disparities in this specific association.
- Findings offer insights for policy development and intervention strategies targeting psychological well-being in aging populations.
Objective:
Despite previous studies illustrate that chronic diseases are risk factors for older adults' psychological health, little is known about its mediating mechanism. This study aims to examine the mediating effect of cognitive impairment. Also, a particular emphasis is placed on whether the Hukou system in China contributes to the adverse effect of chronic diseases on depressive symptoms.
Methods:
Using the 2014, 2016 and 2018 rounds of the China Longitudinal Aging Social Survey (CLASS), this study estimates fixed-effect panel models for the effect of chronic diseases on depressive symptoms and the mediating effect of cognitive impairment. Meanwhile, the interaction effect of chronic diseases and hukou status on depressive symptoms is also examined.
Results:
The significant relationship between chronic diseases and depressive symptoms is supported in Chinese older adults and this association is found to be mediated by cognitive impairment. Moreover, no urban-rural disparities exist in the effect of chronic diseases on depressive symptoms.
Limitation:
All of the measures in this study are relied on self-report, which may result in reporting biases.
Conclusion:
This study contributes to our understanding of the relationship between chronic diseases and depressive symptoms and extends the previous literature by considering the Hukou status, a highly distinctive Chinese variable. Practical implications for policy development and intervention design are also provided.
Related Concept Videos
Cognitive Development During Adulthood
Long-term Depression
Calcium Ion Concentration Mechanism
If over...
Longitudinal Research
Longitudinal Studies
Psychoneuroimmunology: Diabetes and Cancer
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

