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The signaling pathways activated by ROR1 in cancer

María Josefina Quezada1, Pablo Lopez-Bergami1

  • 1Centro de Estudios Biomédicos, Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Buenos Aires 1405, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires 1425, Argentina.

Cellular Signalling
|January 9, 2023
PubMed

Insights

Receptor tyrosine kinase orphan receptor 1 (ROR1) activates multiple signaling pathways in cancer cells, promoting tumor progression. Targeting the WNT5A/ROR1 axis offers a promising therapeutic strategy for various cancers.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Signaling

Background:

  • Receptor tyrosine kinase orphan receptor 1 (ROR1) is a WNT5A receptor crucial for embryonic development.
  • ROR1 regulates cell migration, polarity, neural patterning, and organogenesis via Wnt/PCP and Wnt/Ca++ pathways.

Purpose of the Study:

  • To review signaling pathways regulated by ROR1 in cancer.
  • To elucidate the impact of ROR1 on tumor progression.

Main Methods:

  • Literature review of studies investigating ROR1 signaling in cancer.
  • Analysis of ROR1's role in activating various intracellular pathways.

Main Results:

  • ROR1, beyond Wnt/PCP and Wnt/Ca++ pathways, activates PI3K/AKT, MAPK, NF-κB, STAT3, and Hippo pathways in cancer cells.
  • Aberrant ROR1 expression correlates with tumor progression, invasion, metastasis, and poor survival.

Conclusions:

  • The WNT5A/ROR1 axis significantly contributes to cancer progression through multiple signaling pathways.
  • Targeting ROR1 represents a potential therapeutic strategy for cancer treatment.
Keywords:
AKTMAPKNF-κBROR1STAT3Tyrosine kinaseWNT5Acancer

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