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Related Experiment Video

Updated: Aug 14, 2025

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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Understanding and modeling nerve-cancer interactions.

Thanh T Le1, Madeleine J Oudin1

  • 1Department of Biomedical Engineering, 200 College Avenue, Tufts University, Medford, MA 02155, USA.

Disease Models & Mechanisms
|January 9, 2023
PubMed
Summary

Peripheral nerves significantly influence cancer progression, with higher nerve density linked to worse patient outcomes. Targeting these nerves offers a promising new avenue for cancer treatment strategies.

Keywords:
CancerInnervationModels

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Area of Science:

  • Oncology
  • Neuroscience
  • Cancer Biology

Background:

  • The peripheral nervous system (PNS) is increasingly recognized for its role in cancer progression.
  • Elevated intratumoral nerve density correlates with poorer prognoses across various cancer types.
  • Nerves directly influence tumor cell growth, metastasis, angiogenesis, and the tumor immune microenvironment.

Approach:

  • This review synthesizes current knowledge on the types of peripheral nerves present in tumor microenvironments.
  • It examines mechanisms driving increased nerve density within tumors.
  • The review discusses the multifaceted effects of these nerves on cancer progression.

Key Points:

  • Peripheral nerves directly modulate critical tumor cell behaviors, including proliferation and invasion.
  • Nerve infiltration impacts the tumor's local environment, affecting blood vessel formation and immune cell activity.
  • Understanding nerve-cancer interactions is crucial for developing novel therapeutic strategies.

Conclusions:

  • Further research into the mechanisms of nerve-cancer communication is essential.
  • Developing and refining in vitro and in vivo models are key to advancing this field.
  • Targeting peripheral nerves presents a novel therapeutic frontier for cancer treatment.