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Published on: April 23, 2021
Impact of cerebral microbleeds on cognitive functions and its risk factors in acute cerebral infarction patients
Linyun Chen1, Feng Liu2, Xuan Tian1
1Department of Neurology, Cangzhou People's Hospital, Cangzhou, Hebei, China.
Background:
Cerebral microbleeds (CMBs) are subclinical lesions of the brain parenchyma and an important marker for the clinical diagnosis of central nervous system vascular disease. However, the relationship between CMBs and cerebral infarction, cerebral hemorrhage, and cognitive impairment remains unclear.
Methods:
In order to explore the cognitive function and risk factors of patients with acute cerebral infarction (ACI) complicated with cerebral microbleeds, 190 patients with ACI were collected. The patients were divided into groups with CMBs (n = 108) and groups without CMBs (n = 82) according to the presence or absence of CMBs. The general data, various examination indicators, Montreal Cognitive Assessment Scale (MoCA) scores of the two groups of patients were analyzed. Sixty healthy controls who underwent physical examination in our hospital during the same period were included as the healthy control group.
Results:
ACI patients with CMBs had significantly higher rates of leukoaraiosis, hyperhomocysteinemia, hypercholesterolemia, and hypertension. Cognitive function was significantly lower in ACI patients with CMBs. Serum D-dimer, serum high-sensitivity C-reactive protein, serum neuron-specific enolase, and serum S100β of ACI patients with CMBs were all negatively correlated with their MoCA scores.
Conclusion:
ACI patients with CMBs tended to have lower cognitive abilities than ACI patients without CMBs.
Insights
Cerebral microbleeds (CMBs) are linked to worse cognitive function in patients with acute cerebral infarction (ACI). These patients also show higher rates of vascular risk factors and poorer outcomes on cognitive tests.
Area of Science:
- Neurology
- Vascular Neurology
- Neuroimaging
Background:
- Cerebral microbleeds (CMBs) are subclinical brain lesions and markers of central nervous system vascular disease.
- The association between CMBs and outcomes like cerebral infarction, hemorrhage, and cognitive impairment requires further elucidation.
Purpose of the Study:
- To investigate the cognitive function and associated risk factors in patients diagnosed with acute cerebral infarction (ACI) who also present with cerebral microbleeds (CMBs).
Main Methods:
- A cohort of 190 ACI patients were categorized into groups with (n=108) and without (n=82) CMBs.
- Demographic data, clinical indicators, and Montreal Cognitive Assessment (MoCA) scores were analyzed.
- Sixty healthy individuals served as a control group for comparison.
Main Results:
- ACI patients with CMBs exhibited higher incidences of leukoaraiosis, hyperhomocysteinemia, hypercholesterolemia, and hypertension.
- Cognitive function, assessed by MoCA scores, was significantly diminished in ACI patients with CMBs.
- Elevated levels of serum D-dimer, high-sensitivity C-reactive protein, neuron-specific enolase, and S100β were negatively correlated with MoCA scores in ACI patients with CMBs.
Conclusions:
- Acute cerebral infarction patients with cerebral microbleeds demonstrate a tendency towards reduced cognitive abilities compared to those without CMBs.
