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Current concepts and advances in dermatomyositis: a dermatological perspective
Darosa Lim1, David Fiorentino2, Victoria Werth3
1Dermatology, Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia, and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Clinical and Experimental Rheumatology
|January 9, 2023
Summary
Dermatomyositis (DM) is an autoimmune disease. This review focuses on skin-predominant DM, discussing diagnosis, management, and new treatments for cutaneous manifestations.
Area of Science:
- Dermatology
- Rheumatology
- Immunology
Background:
- Dermatomyositis (DM) is an autoimmune disorder.
- Clinically amyopathic DM (CADM) presents with skin findings but no muscle weakness, accounting for 20% of DM patients.
Purpose of the Study:
- To review current concepts and advances in DM from a dermatological viewpoint.
- To discuss challenges in diagnosing and managing skin-predominant DM.
- To update on classification criteria, pathogenesis, autoantibodies, outcome measures, and therapeutics for cutaneous DM.
Main Methods:
- Literature review of recent advances in dermatomyositis.
- Focus on dermatological perspective and skin-predominant disease.
- Discussion of diagnostic and management challenges, clinical trials, and therapeutics.
Main Results:
- Skin-predominant DM presents unique diagnostic and management challenges.
- Myositis-specific autoantibodies are associated with specific cutaneous findings.
- New therapeutics show efficacy in treating skin disease in DM.
Conclusions:
- Advances in understanding DM pathogenesis and autoantibody associations are crucial.
- Development of skin-specific outcome measures and novel therapeutics is vital for managing cutaneous DM.
- A multidisciplinary approach is essential for optimal patient care in DM.
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