Related Experiment Video

Updated: Aug 14, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

506

Gutted: constipation in children with chronic kidney disease and on dialysis

Mandy Wan1,2, Lillian King3, Natasha Baugh3

  • 1Evelina Pharmacy Department, Evelina London Children's Hospital, NHS Foundation Trust, Guy's and St ThomasWestminster Bridge Road, London, SE1 7EH, UK. mandy.wan@gstt.nhs.uk.

Pediatric Nephrology (Berlin, Germany)
|January 9, 2023
PubMed

Insights

Functional constipation is common in children, especially those with chronic kidney disease (CKD). Effective management is crucial due to unique risk factors and potential gut-kidney interactions in pediatric CKD patients.

Area of Science:

  • Pediatric Nephrology
  • Gastroenterology
  • Gut Microbiome Research

Background:

  • Functional constipation presents unique challenges for children with chronic kidney disease (CKD).
  • CKD patients face additional risks from uremic toxins, dietary/fluid restrictions, reduced activity, and polypharmacy.
  • Constipation significantly impacts pediatric CKD patients and their caregivers, potentially affecting dialysis efficacy.

Approach:

  • This review synthesizes current knowledge on functional constipation in pediatric CKD.
  • It examines the pathophysiology, diagnosis, and epidemiology of constipation in this vulnerable population.
  • The review discusses therapeutic strategies and highlights management challenges.

Key Points:

  • A bidirectional relationship may exist between constipation and CKD, possibly involving gut dysbiosis and increased uremic toxin production.
  • Gut dysbiosis can lead to increased intestinal permeability, systemic inflammation, and contribute to CKD progression.
  • Severe constipation can impair peritoneal dialysis catheter function and ultrafiltration efficiency.

Conclusions:

  • Effective constipation management is essential for pediatric CKD patients.
  • Further research is needed on the safety and efficacy of constipation treatments in children with CKD.
  • Addressing constipation may mitigate systemic inflammation and improve outcomes in pediatric CKD.

Keywords:
Chronic kidney diseaseConstipationDialysisGut microbiotaLaxative

More Related Videos

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

2.0K
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

760

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
67
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
40
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
59
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
54
Dialysis01:27

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
420
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
40