Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The relationship between exercise-induced asthma and plasma catecholamines.

R Dosani1, G R Van Loon, N K Burki

  • 1Department of Medicine, University of Kentucky Medical Center, Lexington 40536-0084.

The American Review of Respiratory Disease
|October 1, 1987
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Viral pericarditis: a report of five cases.

Canadian Medical Association journal·2010
Same author

Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors.

Pulmonary pharmacology & therapeutics·2006
Same author

Effects of therapeutic doses of albuterol on beta2-adrenergic receptor density and metabolic changes.

The Journal of asthma : official journal of the Association for the Care of Asthma·2001
Same author

Maximal expiratory flow patterns after single-lung transplantation in patients with and without chronic airways obstruction.

Chest·2001
Same author

Effects of acute prolonged exposure to high-altitude hypoxia on exercise-induced breathlessness.

Clinical science (London, England : 1979)·1999
Same author

Variability of peripheral blood lymphocyte beta-2-adrenergic receptor density in humans.

American journal of respiratory and critical care medicine·1998

In asthmatics, a second exercise bout causes less bronchoconstriction due to a refractory period. This study explored the link between this refractory response and sympathoadrenal function in asthma patients.

Area of Science:

  • Exercise physiology
  • Pulmonary medicine
  • Biochemistry

Background:

  • Exercise is a known trigger for bronchoconstriction in asthmatics.
  • A subsequent exercise bout within 30-90 minutes elicits a reduced bronchoconstrictor response, a phenomenon termed the refractory period.
  • The physiological basis for this refractory period in asthma remains unclear.

Purpose of the Study:

  • To investigate the relationship between the exercise-induced bronchoconstriction refractory period and sympathoadrenal function in asthmatic individuals.
  • To compare responses in normal subjects, asthmatics without an exercise-induced bronchoconstrictor response, and asthmatics with such a response.

Main Methods:

  • Evaluated 6 healthy subjects and 12 stable asthmatics (divided into two groups based on exercise response).

Related Experiment Videos

  • Subjects underwent two standardized treadmill exercise periods (E1 and E2) separated by 30-90 minutes.
  • Measured spirometry and plasma catecholamine levels (epinephrine, norepinephrine, dopamine) before and at intervals after each exercise period.

    • Main Results:

    • Baseline plasma dopamine levels were significantly higher in asthmatics with an exercise-induced bronchoconstrictor response (Group 3) compared to others.
    • Groups 1 (normal) and 2 (asthmatics without response) showed no significant FEV1 changes after E1 or E2.
    • Group 3 asthmatics exhibited significant FEV1 decline after E1 (-14.4%) and E2 (-8.8%), with a significantly blunted response to E2 compared to E1.

    Conclusions:

    • Elevated baseline plasma dopamine may be associated with exercise-induced bronchoconstriction in asthmatics.
    • The refractory period observed after the second exercise bout in asthmatics is characterized by a significantly reduced decline in FEV1.
    • Sympathoadrenal function, particularly dopamine levels, may play a role in modulating the refractory response to exercise in asthma.