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Comparison of different onset ages in patients with Behcet's disease

Xiaozhen Zhao1, Chao Li1, Caifeng Li2

  • 1Department of Rheumatology, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, No. 56 Nan Li Shi Lu, Beijing, 100045, China.

Clinical Rheumatology
|January 9, 2023
PubMed
Abstract

No abstract available in PubMed .

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

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