Microgravity and Lymphatics: Why Space Programs Need Lymphedema Physiology Specialists

The resurgence of space travel in the recent years, both through formally trained astronauts on the International Space Station and the civilian space race to send astrocivilians to Low Earth Orbit and beyond, beckons the need to understand the role of the lymphatic system and role of endothelial glycocalyx when subjected to gravitational alterations. A comprehensive narrative review of the literature explores a call to action for research and countermeasure development to support the health and well-being of humans subjected to space flight, with particular attention to the role of the lymphatic system and endothelial glycocalyx. Emerging evidence suggests a link between the dysfunction experienced with various physiological processes in microgravity, highlighting the need for more research exploring the role of the lymphatic system in the extremes of gravity and countermeasure development to reduce dysregulation. The synergistic and interdependent relationship of these structures are fundamental to health in space and on Earth.