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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat

Published on: July 3, 2013

Acidosis and growth in nonuremic renal disease

E McSherry

    Kidney International
    |October 1, 1978
    PubMed

    Insights

    Children with type 1 renal tubular acidosis (RTA) require significant alkali therapy for sustained acidosis correction. This treatment promotes catch-up growth and normal stature in affected children.

    Area of Science:

    • Pediatrics
    • Nephrology
    • Endocrinology

    Background:

    • Type 1 renal tubular acidosis (RTA) is characterized by impaired renal bicarbonate reabsorption.
    • Acidosis in RTA can lead to significant growth impairment in children.
    • Optimal alkali dosage for sustained correction remains an area of investigation.

    Purpose of the Study:

    • To determine the sustained efficacy of alkali therapy in correcting acidosis in children with type 1 RTA.
    • To evaluate the impact of sustained acidosis correction on growth and stature in children with type 1 RTA and growth impairment.

    Main Methods:

    • Retrospective analysis of children diagnosed with type 1 RTA.
    • Administration of alkali therapy at doses ranging from 5 to 14 mEq/kg/day.
    • Monitoring of acid-base status and growth parameters.

    Main Results:

    • Sustained correction of acidosis was achieved with alkali therapy doses of 5 to 14 mEq/kg/day.
    • Children with type 1 RTA and growth impairment experienced catch-up growth and attained normal stature.
    • Large alkali doses were necessary due to significant renal bicarbonate-wasting.

    Conclusions:

    • Alkali therapy is effective in sustained acidosis correction in pediatric type 1 RTA.
    • Sustained acidosis correction promotes catch-up growth and normal stature attainment in affected children.
    • Further research is needed to determine the effects of acidosis correction on growth in other renal conditions.

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