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Related Experiment Video

Updated: Aug 14, 2025

Intraductal Injection of LPS as a Mouse Model of Mastitis: Signaling Visualized via an NF-κB Reporter Transgenic
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Unilateral lupus mastitis.

Alicia Jiménez-Antón1, David Jiménez-Gallo1, José Francisco Millán-Cayetano1

  • 1Unidad de Gestión Clínica de Dermatología Médico-Quirúrgica y Venereología, 16824Hospital Universitario Puerta del Mar, Cádiz, Spain.

Lupus
|January 9, 2023
PubMed
Summary

Lupus mastitis, a rare condition linked to lupus erythematosus, requires accurate diagnosis to distinguish it from breast cancer. Hydroxychloroquine effectively treats this condition, as demonstrated in a recent case study.

Keywords:
Cutaneous lupussubacute lupus erythematosussystemic lupus erythematosus

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Area of Science:

  • Dermatology
  • Rheumatology
  • Oncology

Background:

  • Lupus mastitis is an uncommon manifestation of systemic lupus erythematosus (SLE) or discoid lupus erythematosus (DLE).
  • Accurate differentiation from inflammatory breast cancer is crucial for appropriate patient management.
  • Histopathological examination reveals adipose tissue involvement consistent with cutaneous lupus erythematosus.

Observation:

  • A case of unilateral lupus mastitis in a patient without a prior lupus diagnosis was observed.
  • Histological findings confirmed lupus mastitis with characteristic features of cutaneous lupus erythematosus.
  • Direct immunofluorescence identified the lupus band at the dermal-epidermal junction.

Findings:

  • The patient presented with unilateral lupus mastitis.
  • Complete remission was achieved using hydroxychloroquine and topical corticosteroids.
  • This highlights the efficacy of hydroxychloroquine as a primary treatment modality.

Implications:

  • Early and accurate diagnosis of lupus mastitis is essential to avoid misdiagnosis with breast cancer.
  • Hydroxychloroquine is the recommended treatment for lupus mastitis.
  • This case underscores the importance of considering lupus erythematosus in patients presenting with inflammatory breast conditions.