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The Current status of steroid-refractory immune-checkpoint-inhibitor-related hepatotoxicity

Hui Xing1, Yang Wang2, Bo Qu1

  • 1Digestive Department, Second affiliated hospital of Harbin Medical University, No.246 Xuefu Road, Harbin 150086, China.

Translational Oncology
|January 9, 2023
PubMed

ICI-related hepatotoxicity (IRH) is becoming more and more common as immune checkpoint inhibitors (ICIs) have begun to be increasingly approved and used in combination with other anti-tumor drugs worldwide. Steroids are the first choice for the treatment of IRH, but the subsequent optimal treatment algorithm remains unclear if the disease progresses to steroid-refractory IRH. Therefore, in this paper we reviewed all the pertinent literature on steroid-refractory IRH to the greatest extent possible in an attempt to provide information on which to base an update of the treatment algorithm for steroid-refractory IRH.

Keywords:
CholangitisDrug-resistanceHepatitisHepatotoxicityImmune checkpoint inhibitorsSteroid

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