Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dementia01:30

Dementia

153
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
153
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.5K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.5K
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

180
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
180
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

600
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
600
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

199
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
199
Language and Cognition01:27

Language and Cognition

408
Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.
408

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Passive early screening for Alzheimer's disease and related dementias using EHR comorbidity patterns.

NPJ digital medicine·2026
Same author

Depleting prion protein using splice-switching small molecules.

bioRxiv : the preprint server for biology·2026
Same author

Bloodwork-free Early Screening for Alzheimer's Disease via Comorbid Pattern Recognition in Electronic Health Records.

Research square·2026
Same author

Ethnic disparities in patients with early-onset Alzheimer's disease (EOAD).

Frontiers in neurology·2025
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Dementia Care Research and Psychosocial Factors.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025

Related Experiment Video

Updated: Aug 14, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K

Challenging Cases of Neurocognitive Disorders.

James A Mastrianni1, Kaitlin Seibert1

  • 1Department of Neurology, Center for Comprehensive Care and Research on Memory Disorders, University of Chicago, Chicago, Illinois.

Seminars in Neurology
|January 9, 2023
PubMed
Summary

Evaluating dementia requires understanding the underlying disease process, not just cognitive decline. This involves detailed assessment of symptoms, onset, progression, and physical findings for accurate diagnosis and treatment.

More Related Videos

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice
07:18

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

Published on: March 2, 2019

19.2K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.0K

Related Experiment Videos

Last Updated: Aug 14, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.1K
A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice
07:18

A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice

Published on: March 2, 2019

19.2K
Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
07:42

Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients

Published on: December 16, 2022

3.0K

Area of Science:

  • Neurology
  • Neuroscience
  • Geriatrics

Background:

  • Dementia is defined by cognitive decline impacting daily function, but this lacks disease-specific information crucial for developing treatments.
  • Common neurodegenerative dementias include Alzheimer's, Lewy body, frontotemporal, and Parkinson's disease dementia.
  • Prion diseases, though rare, are important considerations in dementia evaluation.

Purpose of the Study:

  • To emphasize the importance of understanding the underlying disease process in dementia evaluation.
  • To highlight the need for a comprehensive approach beyond the broad DSM-V definition.
  • To present cases illustrating the evaluation of atypical dementia presentations.

Main Methods:

  • Review of advances in neuroimaging, biomarkers, and neurogenetics.
  • Detailed patient evaluation considering primary symptoms, age at onset, progression rate, cognitive/behavioral profiles, and physical findings.
  • Case study presentation of atypical dementia presentations.

Main Results:

  • Advances have improved understanding of dementia biology and identified less common subtypes.
  • Comprehensive evaluation requires attention to multiple disease aspects for accurate diagnosis.
  • Case studies demonstrate complex decision-making in atypical dementia cases.

Conclusions:

  • Accurate dementia diagnosis necessitates a detailed evaluation of disease-specific aspects.
  • Understanding the underlying pathology is key for advancing therapeutic development.
  • A thorough, multi-faceted approach is essential for managing patients with cognitive decline.