The oral microbiome in the pathophysiology of cardiovascular disease

Area of Science:

• Microbiology
• Cardiovascular Medicine
• Human Health

Background:

• Cardiovascular diseases (CVDs) remain a leading cause of global mortality despite therapeutic advances.
• The human microbiome's role in health and disease is increasingly recognized, particularly the gut microbiome's link to CVD.
• The impact of oral microbiome dysbiosis on CVD pathogenesis is an emerging area of research.

Purpose of the Study:

• To review the current understanding of the oral microbiome's role in cardiovascular diseases.
• To elucidate the mechanisms linking oral dysbiosis to CVD pathogenesis.
• To explore potential prevention and treatment strategies targeting the oral microbiome.

Main Methods:

• Review of existing scientific literature, including basic science, animal, and human investigations.
• Analysis of multiomics data and high-throughput technologies.
• Examination of the relationship between oral microbiota and specific CVDs.

Main Results:

• Growing evidence suggests a significant link between oral microbiome dysbiosis and CVD.
• Specific CVDs examined include coronary artery disease, stroke, peripheral artery disease, heart failure, infective endocarditis, and rheumatic heart disease.
• Mechanisms by which oral dysbiosis contributes to CVD are being identified.

Conclusions:

• Oral microbiome dysbiosis is a potential contributor to the development and progression of cardiovascular diseases.
• Further research into the oral microbiome offers promising avenues for novel CVD prevention and treatment strategies.
• Targeting the oral microbiome may represent a new therapeutic frontier in managing cardiovascular health.