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Updated: Aug 14, 2025

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
Published on: August 1, 2019
Pragmatic cluster randomized trial to evaluate effectiveness and implementation of EHR-facilitated collaborative
Jeph Herrin1, Lila J Finney Rutten2,3, Kathryn J Ruddy4
1Yale University School of Medicine, New Haven, CT, USA. jeph.herrin@yale.edu.
None:
We previously described the hypotheses, outcomes, design, and analysis for E2C2, a pragmatic stepped-wedge trial to assess an intervention to improve symptom control in patients with cancer. Subsequent consideration of the design and cohort led to the addition of a second primary hypothesis. This article describes and presents the rationale for this second hypothesis. This addendum also details a revised analytic approach, necessitated by inconsistencies in the original analytic plan. The design, outcomes, and other aspects of the protocol remain unchanged.
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