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Updated: Aug 14, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

8.7K

Ghost messages: cell death signals spread

Mingming Zhang1,2, Yuan Lin3, Ruijing Chen1,2

  • 1Department of Orthopedics, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China.

Cell Communication and Signaling : CCS
|January 9, 2023
PubMed

Insights

Dying cells release molecules that act as signals, influencing physiological and pathological processes. Understanding these cell death signals offers potential for new diagnostic and therapeutic strategies.

Area of Science:

  • Cell Biology
  • Molecular Signaling
  • Physiology and Pathology

Background:

  • Cell death, regardless of type, involves the release of signaling molecules.
  • Recent research highlights the communicative role of these released molecules.
  • These signals can influence recipient cells and modulate biological events.

Discussion:

  • This review consolidates knowledge on the types of messages released by dying cells.
  • It examines the impact of these signals on target tissues and cells.
  • The regulatory roles of these intercellular communications in health and disease are explored.

Key Insights:

  • Dying cells actively communicate with their environment through released molecules.
  • These molecular signals play critical roles in both normal physiological functions and disease states.
  • The study of these signals opens avenues for novel therapeutic interventions.

Outlook:

  • Identifies key unanswered questions in the field of cell death signaling.
  • Proposes new hypotheses for future research directions.
  • Suggests potential applications in the development of diagnostic and therapeutic agents.
Keywords:
Cell deathExtracellular vesicleGhost messageIntercellular communicationSoluble factor

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