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Genetic structure and differentiation of human populations
1Department of Human Genetics, University of Newcastle upon Tyne, England.
Abstract:
The concepts of genetic constitution and genetic structure are defined in terms of arrays of gene frequencies, the array and distribution of genotypes, and the distribution of probable ancestral contributions to the gene pool. These concepts can, however, be differentiated. Examples of their application to human populations, to illustrate their descriptive, analytical and epidemiological uses, show that the two concepts help to resolve different types of problems.