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Related Concept Videos

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Updated: Aug 14, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Pharos 2023: an integrated resource for the understudied human proteome.

Keith J Kelleher1, Timothy K Sheils1, Stephen L Mathias2

  • 1National Center for Advancing Translational Science, 9800 Medical Center Drive, Rockville, MD 20850, USA.

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The Illuminating the Druggable Genome (IDG) project enhances understanding of understudied proteins using Target Central Resource Database (TCRD) and Pharos tools. These resources aid disease biology and drug discovery through data visualization and analysis.

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Area of Science:

  • Genomics
  • Pharmacology
  • Bioinformatics

Background:

  • The Illuminating the Druggable Genome (IDG) project focuses on understudied proteins for disease biology and therapeutic development.
  • Key IDG resources include the Target Central Resource Database (TCRD) for data curation and Pharos for data visualization.
  • Previous releases established foundational data aggregation and access.

Purpose of the Study:

  • To detail recent advancements in TCRD and Pharos, focusing on new analysis and visualization tools.
  • To demonstrate how these tools facilitate exploration of disease biology and drug discovery.
  • To showcase the utility of enrichment calculations and interactive charts for biological insights.

Main Methods:

  • Continued development of TCRD for comprehensive target information aggregation.
  • Enhancement of Pharos as a web interface for intuitive data extraction and visualization.
  • Implementation of enrichment calculations and interactive heat maps/UpSet charts for data analysis.

Main Results:

  • TCRD and Pharos now offer advanced tools for analyzing target, disease, and ligand data.
  • Users can perform enrichment calculations on specific data subsets.
  • Interactive visualizations like heat maps and UpSet charts are available for complex annotation analysis.

Conclusions:

  • The updated TCRD/Pharos platform provides powerful capabilities for investigating disease biology.
  • These tools empower researchers to address complex drug discovery questions through data-driven insights.
  • Enhanced data analysis and visualization accelerate the understanding of druggable targets.