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Updated: Aug 14, 2025

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis
Deqiao Qin1, Ling Ma1, Li Qin1
1Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical college, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China.
Abstract:
The skin is the largest barrier organ of the human body and serves to protect the internal structure of the body from the harmful environment. The epidermis forms the outermost layer and is exposed to the environment. Keratinocytes are important constituent cells of the epidermis and alter their morphology and structural integrity through a highly complex differentiation process referred to as cornification. Abnormalities in the process of epidermal cornification can lead to skin barrier dysfunction. The epidermal differentiation complex (EDC) is a gene cluster located within a 2 Mb region of human chromosome 1q21. EDC is responsible for epithelial tissue development and for properties of the stratum corneum. One of the most important features of psoriasis is the abnormal terminal differentiation of keratinocytes. However, the relationship between EDC and the occurrence of psoriasis is still unclear. In this review, we summarize current knowledge regarding the physiological functions of EDC and discuss its possible contributions to the pathogenesis of psoriasis.
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