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Associations Between Korean Coronary Heart Disease Risk Score and Cognitive Function in Dementia-Free Korean Older

Hanbit Mun1,2, Jae-Yong Shim3, Heejin Kimm4

  • 1Department of Family Medicine, Yonsei University College of Medicine, Seoul, Korea.

Journal of Korean Medical Science
|January 10, 2023
PubMed

Insights

High cardiovascular risk is linked to poorer cognitive function in older adults, particularly women. Managing heart health is crucial for maintaining brain health and preventing cognitive decline in the elderly.

Area of Science:

  • Gerontology
  • Cardiology
  • Neurology

Background:

  • Cardiovascular risk is a significant, modifiable factor influencing dementia prevention.
  • Effective dementia treatment options are limited, emphasizing the importance of managing risk factors.
  • This study investigates the relationship between cardiovascular risk and cognitive function in elderly individuals without dementia.

Purpose of the Study:

  • To examine the association between cardiovascular risk, quantified by the Korean coronary heart disease risk score (KRS), and cognitive function.
  • To identify specific demographic groups, such as older women, that may be more vulnerable to cognitive decline associated with cardiovascular risk.

Main Methods:

  • 8,600 dementia-free elderly individuals (average age 69.74, 5,206 women) were analyzed.
  • Korean coronary heart disease risk score (KRS) was calculated based on age, sex, blood pressure, lipids, diabetes, and smoking.
  • Cognitive function was assessed using the Korean Dementia Screening Questionnaire-Cognition (KDSQ-C), with scores ≥ 6 indicating decline. Logistic regression was employed for analysis, adjusting for various health and lifestyle factors.

Main Results:

  • Individuals in the highest KRS group showed a significantly increased risk of cognitive decline compared to the lowest KRS group (OR, 1.339; P=0.027).
  • Older women aged 71-75 in the highest KRS group exhibited a notably higher risk of cognitive decline than their lowest KRS counterparts (OR, 1.595; P=0.031).

Conclusions:

  • Elevated cardiovascular risk is associated with diminished cognitive function, especially in older women.
  • Proactive management of cardiovascular risk factors is essential for promoting healthy cognitive aging in the elderly population.
  • This highlights the critical role of cardiovascular health in preserving cognitive function and potentially preventing dementia.
Abstract

Keywords:
CognitionCognitive DysfunctionHeart Disease Risk FactorsKorean Coronary Heart Disease Risk ScoreKorean Dementia Screening Questionnaire-Cognition

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