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Related Concept Videos

Diabetes Mellitus: Overview and Type I Subtype01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
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Diabetes Mellitus: Type 2 and Gestational01:22

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Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
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Diabetes: Symptoms, Diagnosis, and Complications01:15

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For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
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Insulin: Dosing Regimen and Adverse Effects01:16

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Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
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Pathophysiology of Diabetes01:20

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Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
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Psychoneuroimmunology: Diabetes and Cancer01:19

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Related Experiment Video

Updated: Aug 14, 2025

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Adult-Onset Type 1 Diabetes Development Following COVID-19 mRNA Vaccination.

Hyeyeon Moon1, Sunghwan Suh1, Mi Kyoung Park2

  • 1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

Journal of Korean Medical Science
|January 10, 2023
PubMed
Summary

COVID-19 mRNA vaccines may trigger new-onset type 1 diabetes in adults. This case report details the oldest patient diagnosed with vaccine-associated type 1 diabetes without diabetic ketoacidosis.

Keywords:
COVID-19Type 1 DiabetesVaccinationmRNA Vaccines

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Area of Science:

  • Endocrinology
  • Immunology
  • Vaccinology

Background:

  • Reports of hyperglycemia and complications post-COVID-19 vaccination exist.
  • Few cases link COVID-19 vaccines to new-onset type 1 diabetes in non-diabetic individuals.

Observation:

  • A 56-year-old female without prior diabetes history developed hyperglycemia after mRNA COVID-19 vaccination.
  • She presented with uncontrolled hyperglycemia, high initial HbA1c (11.0%), and normal fasting C-peptide.
  • Subsequent C-peptide decline and positive anti-GAD antibodies indicated autoimmune diabetes.

Findings:

  • This is the first reported case of type 1 diabetes onset without diabetic ketoacidosis following mRNA COVID-19 vaccination.
  • The patient represents the oldest documented case of vaccine-associated type 1 diabetes.
  • Insulin therapy was initiated for stable management.

Implications:

  • Highlights a potential autoimmune complication of mRNA COVID-19 vaccines.
  • Suggests the need for vigilance regarding new-onset diabetes in vaccinated individuals.
  • Contributes to understanding rare adverse events following immunization.