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Understanding COVID-19 imaging across its phases aids diagnosis and treatment. Vaccination significantly reduces severe illness, though long COVID presents ongoing challenges for radiology.

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Area of Science:

  • Radiology
  • Infectious Diseases
  • Public Health

Background:

  • COVID-19 pandemic caused unprecedented global morbidity.
  • Imaging plays a crucial role in diagnosis, severity stratification, and sequelae identification.
  • Disease progression involves distinct early infectious, pulmonary, and hyperinflammatory phases.

Purpose of the Study:

  • To provide comprehensive insights into COVID-19 imaging features.
  • To correlate imaging findings with clinical phases and management strategies.
  • To evaluate the impact of vaccination and identify long-term sequelae.

Main Methods:

  • Review of clinical and imaging features of COVID-19.
  • Analysis of CT findings across different disease phases (early, pulmonary, hyperinflammatory).
  • Assessment of vaccine efficacy and post-acute COVID-19 imaging changes.

Main Results:

  • Early phase: peripheral ground-glass opacities on CT; SARS-CoV-2 targeted therapy effective.
  • Later phase: organizing pneumonia/diffuse alveolar damage on CT; anti-inflammatory therapy beneficial.
  • Omicron variant and breakthrough infections show lower severe disease risk; fourth mRNA vaccine dose shows significant protection.
  • Post-acute residual CT abnormalities may persist as linear or cystic lesions.

Conclusions:

  • Imaging insights into COVID-19 pathophysiology and phases guide diagnosis and treatment.
  • Vaccination offers substantial protection against severe COVID-19 illness and hospitalization.
  • Long COVID presents new diagnostic and management challenges for the radiology field.