Related Experiment Videos
Prognostic indices of typhoid perforation
A H Rathore1, I A Khan, W Saghir
1Department of Surgery, Quaid-i-Azam Medical College, Bahawalpur, Pakistan.
Annals of Tropical Medicine and Parasitology
|June 1, 1987
Summary
Early surgical intervention for typhoid perforation significantly improves survival chances. Prompt treatment within the first week of fever and specific surgical techniques like ileal resection with anastomosis are linked to better outcomes in typhoid perforation cases.
Area of Science:
- Medicine
- Surgery
- Infectious Diseases
Background:
- Typhoid perforation is a serious complication of Salmonella Typhi infection.
- High post-operative mortality rates are a concern in managing typhoid perforation.
Purpose of the Study:
- To analyze factors influencing survival in surgically treated typhoid perforation cases.
- To identify prognostic indicators for patients with typhoid perforation.
Main Methods:
- Retrospective review of 58 surgically treated typhoid perforation cases.
- Analysis of clinical data including fever duration, time to surgery, serology, perforation size, and surgical procedure.
Main Results:
- Survival is better if perforation occurs within the first week of fever.
- Longer delay between perforation and surgery correlates with worse prognosis.
- Negative Widal tests and high 'H' antigen titers are associated with improved survival.
- Ileal resection with end-to-end anastomosis appears to offer the best prognosis.
Conclusions:
- Prognosis for typhoid perforation depends on early presentation and surgical timing.
- Specific surgical approaches, such as ileal resection, may improve outcomes.
- Serological markers can provide prognostic information in typhoid perforation management.