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Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
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Cannabis as antivirals
Yi Lin Sea1, Yee Jing Gee1, Sunil Kumar Lal1,2
1School of Science, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia.
Journal of Applied Microbiology
|January 10, 2023
Summary
Cannabis compounds, including cannabinoids and terpenes, show significant potential as novel antiviral therapeutics. Research indicates their ability to combat viral infections like SARS-CoV-2 by inhibiting replication and reducing inflammation.
Area of Science:
- Pharmacology
- Virology
- Phytochemistry
Background:
- Cannabis possesses over 400 compounds with therapeutic properties, widely recognized for medicinal and recreational use.
- Cannabinoids, such as cannabidiol and delta-9-tetrahydrocannabinol, have demonstrated antiviral effects against various viruses.
- Terpenes, another class of cannabis compounds, are also being explored for their antiviral potential.
Approach:
- This review synthesizes existing research on the antiviral properties of cannabis compounds.
- Focuses on the mechanisms by which cannabinoids and terpenes combat viral infections.
- Examines the efficacy against specific viruses including SARS-CoV-2, HIV, HCV, and HSV-1.
Key Points:
- Cannabinoids can downregulate ACE2 transcript levels and possess anti-inflammatory properties, crucial for combating SARS-CoV-2.
- Cannabinoids act as main protease inhibitors, effectively blocking viral replication.
- Cannabis-derived compounds offer a promising avenue for developing new antiviral treatments.
Conclusions:
- Cannabis compounds, particularly cannabinoids and terpenes, exhibit significant potential as novel antiviral therapeutics.
- Further research into these compounds could lead to effective treatments for a range of viral diseases.
- The multifaceted properties of cannabis constituents warrant their consideration in antiviral drug discovery.
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