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Metabolic disorder and intestinal microflora dysbiosis in chronic inflammatory demyelinating polyradiculoneuropathy
Jiafang Fu1,2,3, Jingli Shan4, Yazhou Cui1,2,3
1Biomedical Sciences College & Shandong Medicinal Biotechnology Centre, First Affiliated Hospital of Shandong First Medical University, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China.
Objective:
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare acquired immune-mediated neuropathy. Although microbial infection is potentially a contributing factor, a causative link between CIDP and microbial infection remains unclear. There is also no definitive biomarker for CIDP diagnostics and therapies. The present study aimed to characterize the serum metabolic profile and gut microbiome structure in CIDP.
Methods:
Targeted metabolomics profiling of serum, using liquid chromatography-mass spectrometry, and metagenomics sequencing of stool samples from a cohort of CIDP and non-CIDP subjects were performed to evaluate serum metabolic profiles and gut microbiome structure in CIDP subjects relative to healthy controls.
Results:
Metabolome data revealed that the bile acids profile was perturbed in CIDP with bile acids and arachidonic acid enriched significantly in CIDP versus non-CIDP controls. Metagenome data revealed that opportunistic pathogens, such as Klebsiella pneumonia and Megamonas funiformis, and genes involved in bacterial infection were notably more abundant in CIDP subjects, while gut microbes related to biotransformation of secondary bile acids were abnormal in CIDP versus non-CIDP subjects. Correlation analysis revealed that changes in secondary bile acids were associated with altered gut microbes, including Bacteroides ovatus, Bacteroides caccae, and Ruminococcus gnavus.
Conclusion:
Bile acids and arachidonic acid metabolism were disturbed in CIDP subjects and might be affected by the dysbiosis of gut microbial flora. These findings suggest that the combination of bile acids and arachidonic acid could be used as a CIDP biomarker and that modulation of gut microbiota might impact the clinical course of CIDP.
Insights
Altered bile acids and arachidonic acid metabolism, linked to gut microbiome changes, are found in Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP). These may serve as biomarkers and offer therapeutic targets for CIDP.
Area of Science:
- Neurology
- Immunology
- Microbiome Research
Background:
- Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) is a rare immune-mediated neuropathy with unclear links to microbial infection.
- Current diagnostics and therapies for CIDP lack definitive biomarkers.
Purpose of the Study:
- To characterize the serum metabolic profile in CIDP patients.
- To analyze the gut microbiome structure in CIDP patients.
- To identify potential biomarkers and therapeutic strategies for CIDP.
Main Methods:
- Serum samples underwent targeted metabolomics profiling using liquid chromatography-mass spectrometry.
- Stool samples were analyzed using metagenomics sequencing.
- CIDP and non-CIDP subjects were compared to identify differences in metabolic profiles and gut microbiome.
Main Results:
- CIDP patients showed perturbed bile acid profiles, with enrichment of bile acids and arachidonic acid.
- Increased abundance of opportunistic pathogens (e.g., Klebsiella pneumonia) and bacterial infection genes were observed in CIDP subjects.
- Alterations in gut microbes involved in secondary bile acid biotransformation were noted, correlating with changes in specific bacteria.
Conclusions:
- Disturbances in bile acid and arachidonic acid metabolism in CIDP may be influenced by gut dysbiosis.
- Bile acids and arachidonic acid show potential as biomarkers for CIDP diagnosis and therapy.
- Modulating the gut microbiota could be a viable strategy to impact the clinical course of CIDP.
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