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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Distinctive Features of Adult Stem Cells vs Cancer Stem Cells01:18

Distinctive Features of Adult Stem Cells vs Cancer Stem Cells

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A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
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Related Experiment Video

Updated: Aug 14, 2025

Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats
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Biomaterial Based Stem Cells Therapy for Cancer.

Akanksha Pandey1, Rishabha Malviya1, Pramod Kumar Sharma1

  • 1Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

Current Stem Cell Research & Therapy
|January 11, 2023
PubMed
Summary

Biomaterials support regenerative medicine by providing scaffolds for stem cells and delivering therapeutic factors. These advanced materials are crucial for tissue engineering and fighting diseases like cancer.

Keywords:
Stem cell therapybiomaterialcancercancer treatmentcollagenpatient care

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Area of Science:

  • Biomaterials science
  • Regenerative medicine
  • Cancer stem cell biology

Background:

  • Biomaterials are engineered to support cell growth and deliver therapeutic agents, crucial for regenerative medicine.
  • Stem cells are increasingly used with biomaterial scaffolds to enhance therapeutic outcomes.
  • Biomaterials aim to mimic the native stem cell niche's physical and biochemical properties.

Purpose of the Study:

  • To explore the role of biomaterials in regenerative medicine and cancer stem cell research.
  • To highlight the potential of biomaterials in creating effective therapeutic strategies.
  • To discuss the application of biomaterials in tissue engineering and immune cell replenishment.

Main Methods:

  • Review of advanced biomaterials including metals, synthetic polymers, ceramics, alginate, and chitosan.
  • Analysis of collagen's role in tumor extracellular matrix and cancer stem cell functions.
  • Investigation of collagen I-based platforms for liver cancer stem cell enhancement.

Main Results:

  • Biomaterials provide essential frameworks for cell adhesion, proliferation, and bioactive factor delivery.
  • Specific collagen subtypes are implicated in cancer initiation, epithelial-mesenchymal transition, drug resistance, and cancer stem cell self-renewal.
  • Collagen I-based platforms show potential in enhancing liver cancer stem cells.

Conclusions:

  • Biomaterial-based therapies offer versatile and tailorable approaches for disease treatment.
  • Biomaterials can serve as tissue-engineered scaffolds for immune cell replenishment.
  • These materials represent a significant advancement in next-generation therapeutic strategies.