Related Experiment Video
Updated: Aug 14, 2025
Isolation of Precursor B-cell Subsets from Umbilical Cord Blood
Published on: April 16, 2013
Autoimmune Hemolytic Anemia After Cord Blood Transplantation: A Retrospective Single-Center Experience
Jing Yuan1, Ze-Yin Liang2, Yu-Jun Dong2
1Department of Hematology, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Objective:
To describe the incidence, possible risk factors, and treatment options of autoimmune hemolytic anemia (AIHA) occurring after cord blood transplantation (CBT).
Methods:
We retrospectively analyzed the patients who underwent CBT at Peking University First Hospital between January 2004 and July 2022.
Results:
We totally identified thirty-six patients who received CBT. Median age was 27.5 years (range, 1.6-52). With a median 6 (range 0.6-10.0) years survivor follow-up, six patients developed AIHA (2 Evans syndrome included) at a median of 168 (range, 122-264) days post-CBT for 8% cumulative incidence density 3 years. Its mortality was 50% and mainly associated with concomitant infections (CMV reactivation rate nearly 100%). The possible risk factors for developing AIHA are CMV reactivation, GvHD and HLA mismatch.
Conclusion:
AIHA is a clinically significant common complication in recipients post-CBT. Corticosteroids combined with intravenous immunoglobulin (IvIg) is recommended for the treatment of warm antibody AIHA after CBT.
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