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Related Experiment Videos

Thin malignant melanomas and recurrence potential.

H M Shaw1, W H McCarthy, S W McCarthy

  • 1Sydney Melanoma Unit, Department of Surgery, University of Sydney, Camperdown, Australia.

Archives of Surgery (Chicago, Ill. : 1960)
|October 1, 1987
PubMed
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Thin malignant melanoma recurrence is higher for scalp lesions and those with ulceration or high mitotic grade. Certain prognostic indicators can help identify patients who may benefit from lymph node dissection.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Malignant melanoma is a significant skin cancer.
  • Early-stage melanoma requires accurate prognostic indicators for treatment decisions.

Purpose of the Study:

  • To identify prognostic factors for recurrence in thin (less than 0.76 mm) stage I malignant melanoma.
  • To determine which patients might benefit from elective lymph node dissection.

Main Methods:

  • Retrospective analysis of 846 patients with stage I malignant melanoma followed for 2-31 years.
  • Evaluation of lesion location, ulceration, mitotic rate, Clark's level, and regression as prognostic indicators.

Main Results:

  • Overall recurrence rate was 7.2% (61/846).

Related Experiment Videos

  • Scalp lesions had a higher recurrence rate (15%) compared to extremity lesions (4%).
  • Ulceration (26.1% vs 6.7%), high mitotic grade (23.8% vs 4.3%), and Clark's level III/IV (12% vs 5% for level II) significantly increased recurrence risk.

    • Conclusions:

    • Specific histological features and lesion location are key predictors of recurrence in thin melanomas.
    • A subset of patients with high-risk features may benefit from elective lymph node dissection.