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A rare case report: vaginal paraganglioma
1Department of Gynecology, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology) Shenzhen 518020, Guangdong, China.
American Journal of Translational Research
|January 11, 2023
Summary
This report details a rare case of vaginal paraganglioma (VP) in a 39-year-old woman with hypercatecholaminism. Successful laparoscopic removal offers insights into managing this uncommon tumor.
Area of Science:
- Endocrinology
- Gynecologic Oncology
- Surgical Pathology
Background:
- Vaginal paraganglioma (VP) is a rare tumor originating from the anterior neural crest, classified as functional or non-functional.
- Fewer than 10 cases of VP have been documented since 1955, highlighting its extreme rarity.
Observation:
- A 39-year-old female presented with symptoms of hypercatecholaminism and a family history of hypertension.
- Intraoperative blood pressure fluctuations occurred upon tumor manipulation, necessitating careful management.
- Laparoscopic surgery enabled successful and complete tumor excision under anesthesia.
Findings:
- Postoperative pathology confirmed the diagnosis of vaginal paraganglioma.
- The case exhibited characteristics of a functional tumor, indicated by hypercatecholaminism and intraoperative hypertensive crisis.
- Review of prior literature (10 cases) alongside this case provides a broader understanding of VP.
Implications:
- This case underscores the importance of considering rare tumors like VP in patients with unexplained hypercatecholaminism and hypertension.
- Preoperative alpha-receptor blockade is crucial for managing potential hypertensive crises.
- Successful laparoscopic resection demonstrates the feasibility of minimally invasive treatment for VP.
