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Radiomics analysis of unaffected side changes in classic trigeminal neuralgia
Lei Pan1, Haiqi Ye1, Xiaofen Zhu1
1Department of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine Hangzhou 310000, Zhejiang, China.
American Journal of Translational Research
|January 11, 2023
Summary
Radiomics revealed structural differences in the unaffected trigeminal nerve of patients with classic trigeminal neuralgia (CTN). These findings suggest NVC is not essential for CTN and highlight potential congenital or secondary factors.
Area of Science:
- Neurology
- Radiology
- Medical Imaging
Background:
- Classic trigeminal neuralgia (CTN) is a debilitating condition affecting the trigeminal nerve.
- The precise etiological mechanisms underlying CTN remain incompletely understood.
- Investigating structural changes in the unaffected nerve may offer new insights.
Purpose of the Study:
- To utilize radiomics to identify subtle structural differences in the unaffected trigeminal nerve between CTN patients and healthy controls (HCs).
- To explore the potential etiological mechanisms of trigeminal neuralgia (TN) by analyzing these structural variations.
Main Methods:
- Retrospective analysis of MRI data from 95 CTN patients and 89 HCs.
- Grouping based on the presence or absence of neurovascular compression (NVC) on the unaffected trigeminal nerve.
- Manual delineation of trigeminal cisternal segments, followed by feature extraction, dimensionality reduction, and model construction.
Main Results:
- Distinct radiomic signatures were identified in HCs with and without NVC, and in CTN patients without NVC on the unaffected side.
- A statistically significant difference in the Rad_score was observed between groups (P < 0.05).
- The developed radiomics model demonstrated high accuracy and consistency between training and validation sets.
Conclusions:
- Neurovascular compression (NVC) can alter trigeminal nerve structure, but it is not a prerequisite for CTN development.
- The high incidence of NVC in asymptomatic individuals necessitates severity grading.
- Observed differences in the unaffected nerve characteristics between CTN patients and HCs may stem from congenital or secondary factors.
