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Dysfunctional network of hub genes in hypertrophic cardiomyopathy patients

Shan Wu1, Iqtidar Ud Din2, Faisal Mahmood Sadiq3

  • 1Wuhu No. 1 People's Hospital Wuhu 241000, Anhui, China.

American Journal of Translational Research
|January 11, 2023
PubMed

Insights

Ten key genes are linked to hypertrophic cardiomyopathy (HCM) development. These identified hub genes offer potential as biomarkers and therapeutic targets for managing HCM.

Area of Science:

  • Genomics
  • Cardiovascular Research
  • Molecular Biology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a major cause of sudden cardiac arrest.
  • Effective treatments for HCM are currently limited.
  • Identifying HCM-associated hub genes is crucial for diagnosis and developing therapeutic strategies.

Purpose of the Study:

  • To identify differentially expressed genes (DEGs) in HCM.
  • To identify hub genes associated with HCM.
  • To construct a regulatory network and analyze the function of hub genes.

Main Methods:

  • Analyzed HCM gene expression datasets (GSE36961, GSE32453) from the GEO database.
  • Utilized GEOR2, STRING, and Cytoscape for DEG and hub gene identification.
  • Constructed a lncRNA-cricRNA-miRNA-mRNA regulatory network and performed pathway analysis using DAVID.

Main Results:

  • Identified 262 significant DEGs (162 down-regulated, 76 up-regulated) in HCM patients.
  • Shortlisted 10 down-regulated hub genes: CD14, ITGB2, C1QB, CD163, HCLS1, ALOX5AP, PLEK, C1QC, FCER1G, and TYROBP.
  • Hub genes are implicated in pathways such as Pertussis, Complement and coagulation cascade, and Asthma; regulatory network identified key miRNAs, lncRNA, and cricRNA.

Conclusions:

  • Ten hub genes (CD14, ITGB2, C1QB, CD163, HCLS1, ALOX5AP, PLEK, C1QC, FCER1G, TYROBP) are integral to HCM development and progression.
  • These genes show potential as diagnostic biomarkers for HCM.
  • The identified hub genes represent promising therapeutic targets for HCM treatment.
Abstract

Keywords:
Hypertrophic cardiomyopathybiomarkerhub genesmiRNAstherapeutic target

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