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Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation
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Engineering Cyborg Bacteria Through Intracellular Hydrogelation.

Luis E Contreras-Llano1, Yu-Han Liu2, Tanner Henson1,3

  • 1Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 11, 2023
PubMed
Summary
This summary is machine-generated.

Researchers engineered hybrid "Cyborg Cells" by creating synthetic polymer networks within bacteria, preventing replication. These modified cells retain vital functions and show therapeutic potential by invading cancer cells.

Keywords:
cellular chassishybrid materialhydrogelnonculturable cellsnonreplicating bacteriasynthetic biology

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Area of Science:

  • Synthetic biology
  • Cellular bioengineering
  • Biomaterials

Background:

  • Natural cells offer complex functions but pose safety risks due to replication in synthetic biology.
  • Artificial cells provide control but lack the biochemical complexity of natural cells.
  • A need exists for controllable cellular entities with reduced safety concerns for biomedical applications.

Purpose of the Study:

  • To create novel hybrid material-cell entities, termed Cyborg Cells, by integrating synthetic polymers within living bacteria.
  • To assess the functional capabilities and safety profile of these Cyborg Cells.
  • To explore the therapeutic potential of Cyborg Cells in cancer treatment.

Main Methods:

  • Assembly of synthetic polymer networks within individual bacterial cells to inhibit cell division.
  • Characterization of Cyborg Cell functions, including metabolism, motility, protein synthesis, and genetic circuit compatibility.
  • Evaluation of Cyborg Cell resistance to environmental stressors.
  • Demonstration of Cyborg Cell invasion into cancer cells.

Main Results:

  • Successful creation of Cyborg Cells, which are non-replicating bacterial entities.
  • Preservation of essential cellular functions such as metabolism, motility, and protein synthesis.
  • Enhanced resistance of Cyborg Cells to stressors that are lethal to natural cells.
  • Demonstrated ability of Cyborg Cells to invade cancer cells, indicating therapeutic potential.

Conclusions:

  • Cyborg Cells represent a new paradigm in cellular bioengineering, merging synthetic polymers with living cell machinery.
  • This approach offers enhanced control and safety for cellular applications by preventing replication.
  • Cyborg Cells exhibit promising therapeutic potential, particularly in cancer therapy, due to their unique properties.