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Related Experiment Video

Updated: Aug 14, 2025

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Photodegradable Hydrogel Interfaces for Bacteria Screening, Selection, and Isolation

Published on: November 4, 2021

Engineering Cyborg Bacteria Through Intracellular Hydrogelation.

Luis E Contreras-Llano¹, Yu-Han Liu², Tanner Henson^1,3

¹Department of Biomedical Engineering, University of California, Davis, CA, 95616, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|January 11, 2023

Summary

This summary is machine-generated.

Researchers engineered hybrid "Cyborg Cells" by creating synthetic polymer networks within bacteria, preventing replication. These modified cells retain vital functions and show therapeutic potential by invading cancer cells.

Keywords:

cellular chassis hybrid material hydrogel nonculturable cells nonreplicating bacteria synthetic biology

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Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications

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Published on: August 4, 2017

Area of Science:

Synthetic biology
Cellular bioengineering
Biomaterials

Background:

Natural cells offer complex functions but pose safety risks due to replication in synthetic biology.
Artificial cells provide control but lack the biochemical complexity of natural cells.
A need exists for controllable cellular entities with reduced safety concerns for biomedical applications.

Purpose of the Study:

To create novel hybrid material-cell entities, termed Cyborg Cells, by integrating synthetic polymers within living bacteria.
To assess the functional capabilities and safety profile of these Cyborg Cells.
To explore the therapeutic potential of Cyborg Cells in cancer treatment.

Main Methods:

Assembly of synthetic polymer networks within individual bacterial cells to inhibit cell division.
Characterization of Cyborg Cell functions, including metabolism, motility, protein synthesis, and genetic circuit compatibility.
Evaluation of Cyborg Cell resistance to environmental stressors.
Demonstration of Cyborg Cell invasion into cancer cells.

Main Results:

Successful creation of Cyborg Cells, which are non-replicating bacterial entities.
Preservation of essential cellular functions such as metabolism, motility, and protein synthesis.
Enhanced resistance of Cyborg Cells to stressors that are lethal to natural cells.
Demonstrated ability of Cyborg Cells to invade cancer cells, indicating therapeutic potential.

Conclusions:

Cyborg Cells represent a new paradigm in cellular bioengineering, merging synthetic polymers with living cell machinery.
This approach offers enhanced control and safety for cellular applications by preventing replication.
Cyborg Cells exhibit promising therapeutic potential, particularly in cancer therapy, due to their unique properties.