Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

651
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
651
Lifecycle of Erythrocytes01:22

Lifecycle of Erythrocytes

2.1K
Erythrocytes, also known as red blood cells, constantly move through blood capillaries. As a result, they damage their plasma membrane due to the continuous friction. Typically, after 100 to 120 days, erythrocytes become rigid and fragile as they wear out. As they pass through small vessels in the spleen and liver, they can get trapped and break apart into fragments.
The resident phagocytic macrophages deal with these damaged cells by engulfing them and separating their globin and heme groups....
2.1K
Erythropoiesis01:14

Erythropoiesis

4.5K
Red blood cells  (RBCs) transport oxygen to all body tissues. These cells survive only for 120 days and then need to be replenished. Erythropoiesis is the process of RBC production. In healthy individuals, erythropoiesis ensures all tissues are amply supplied with oxygen. In addition, blood loss due to injury leads to a drop in the physiological oxygen level that will cause erythropoiesis. Any defect in erythropoiesis leads to several physiological disorders, including thalassemia, anemia,...
4.5K
Structure and Function of Erythrocytes01:29

Structure and Function of Erythrocytes

2.2K
There are between 4.2 and 6 million erythrocytes, also known as red blood cells, in every microliter of blood. These cells are small, flattened biconcave discs with centers that are depressed.
The erythrocyte plasma membrane is associated with proteins such as spectrin, which forms a flexible cytoplasmic meshwork. This meshwork allows erythrocytes to twist, turn, become cup-shaped, and regain their biconcave shape as they pass through narrow capillaries. Additionally, erythrocytes can form...
2.2K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

386
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
386
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

11.0K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
11.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel US-based grading system for disease severity in sickle cell disease: the Sickle Cell Outcome Grading System (SCOGS).

The Lancet. Haematology·2026
Same author

The Use of Nitrous Oxide for Routine Dental Treatment in Pediatric Patients with Sickle Cell Disease.

Pediatric dentistry·2026
Same author

Targeting erythroid cell-derived asparagine inhibits alloimmunization in sickle cell disease.

Blood advances·2026
Same author

Red cell antibody and antigen patterns in patients with sickle cell disease: A multi-center analysis.

Transfusion·2026
Same author

Validating the Recorded Electronic Health Record (EHR) and Actual Weight: Single Institution Study.

Journal of clinical apheresis·2026
Same author

Meniscus Tear Morphology and Patient Demographics as Predictors of Treatment for Meniscal Tears: A Natural Language Processing Study.

Orthopaedic journal of sports medicine·2026

Related Experiment Video

Updated: Aug 14, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.6K

How do we operate a large monthly red blood cell exchange program.

David Allison1, Luis Manon1, Vladimir Vidanovic1

  • 1Department of Pathology, University of Illinois at Chicago, Chicago, Illinois, USA.

Transfusion
|January 11, 2023
PubMed
Summary
This summary is machine-generated.

Managing red blood cell (RBC) exchange for sickle cell disease requires careful planning. Multidisciplinary teamwork and improved processes ensure successful monthly treatments for patients.

Keywords:
red blood cell exchangesickle cell diseasetherapeutic apheresis

More Related Videos

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.1K

Related Experiment Videos

Last Updated: Aug 14, 2025

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

19.6K
A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.8K
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

18.1K

Area of Science:

  • Hematology
  • Transfusion Medicine
  • Vascular Access

Background:

  • Sickle cell disease (SCD) patients undergoing chronic red blood cell (RBC) exchange face challenges including RBC phenotyping, antibody screening, unit requirements, and vascular access.
  • These complexities can lead to procedural delays, emphasizing the need for robust systemic processes.

Observation:

  • A high-volume chronic RBC exchange program successfully manages approximately 50 outpatient procedures monthly with an 82% appointment adherence rate.
  • Key success factors include enhanced multidisciplinary coordination and process improvements in patient referral, vascular access management, standardized order sets, and allocation of antigen-negative or phenotypically matched RBCs.

Findings:

  • Open communication across referring hematologists, hemapheresis clinics, transfusion services, and interventional radiology is critical for maintaining appointment schedules.
  • Advance notification to the immunohematology reference laboratory is essential for timely allocation of antigen-negative RBCs.
  • Standardized order sets streamline the RBC exchange process, contributing to program efficiency.

Implications:

  • Multidisciplinary coordination and continuous process improvement are vital for the success of high-volume chronic RBC exchange programs in SCD.
  • Effective communication and streamlined workflows ensure timely and safe RBC exchange procedures, optimizing patient care.
  • Strategies for managing RBC exchange in SCD can be adapted to other complex transfusion protocols requiring significant logistical coordination.