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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...
Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

Updated: Jun 12, 2026

Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Microneedle-based transdermal detection and sensing devices.

Junxia Wang1, Ziyi Lu1,2, Ruisi Cai1

  • 1Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China. yqzhang21@zju.edu.cn.

Lab on a Chip
|January 11, 2023
PubMed
Summary
This summary is machine-generated.

Microneedles offer minimally invasive, highly integrated biosensors for personalized health. This review covers microneedle designs, detection targets, sensing principles, and future challenges for advanced biosensing applications.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Sensor Technology

Background:

  • Microneedles are emerging as key components for next-generation biosensors.
  • Their minimal invasiveness, high integration, and biocompatibility are advantageous for personalized and digitized health monitoring.
  • Current research focuses on optimizing microneedle design and sensing capabilities.

Purpose of the Study:

  • To provide a comprehensive overview of state-of-the-art microneedle-based detection and sensing systems.
  • To summarize microneedle device designs, detection targets, and sensing principles.
  • To discuss challenges and future perspectives in microneedle biosensor development.

Main Methods:

  • Review of microneedle device designs based on extraction mechanisms, considering various geometries and materials.
  • Summarization of targets for equipment-assisted microneedle detections and their significance.
  • Elaboration on sensing principles, including colorimetric, fluorometric, and electronic methods for integrated sensors.

Main Results:

  • Analysis of diverse microneedle designs and materials for biosensing applications.
  • Identification of current performance and potential scenarios for microneedle-based detection.
  • Highlighting the trend towards highly integrated biosensors utilizing various sensing modalities.

Conclusions:

  • Microneedle biosensors represent a promising platform for advanced diagnostics and personalized medicine.
  • Further development is needed to address key challenges in integration, sensitivity, and real-world application.
  • Future research should focus on enhancing sensing capabilities and exploring novel materials and designs.